Breathlessness in adults: IPCRG desktop helper for primary care physicians

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Khouloud Kchaou
Gillian Doe
Ann Hutchinson
Jacob Sandberg
Anthony Sunjaya
Helmi Ben Saad
Siân Williams

Abstract

Background: Breathlessness is common, anxiety-provoking, and challenging to clarify in primary care. When it persists beyond four weeks, it markedly
impairs quality of life, functional capacity, and prognosis, and can trigger urgent consultations if underlying causes are not recognized and managed. Chronic breathlessness is frequently multifactorial, combining cardiopulmonary disease with obesity, deconditioning, breathing pattern disorders, anxiety, anemia, and post-coronavirus disease 2019 conditions.
Objective: This technical sheet aimed to provide primary care physicians with a structured, pragmatic, person-centered approach to the assessment and
management of chronic breathlessness.
Content: This technical sheet emphasized early identification of acute/urgent presentations of breathlessness in adults (including pulse oximetry when available), systematic evaluation (history, examination, accessible investigations such as spirometry, chest radiography, electrocardiogram, complete blood count, N-terminal pro–B-type natriuretic peptide, and screening for anxiety/depression and physical activity level), and staged diagnostic reasoning that may require several visits while safely managing uncertainty. Management includes optimizing treatment of underlying conditions according to national guidance and early introduction of evidence-based non-pharmacological strategies. The breathing–thinking–functioning model is proposed to structure symptom control: correcting maladaptive breathing patterns, addressing fear and distress, and tackling deconditioning through appropriate rehabilitation and activity support.
Conclusion: A structured primary-care pathway combined with early non-pharmacological interventions can improve consultations, support self-
management, and enhance outcomes in adults with chronic breathlessness.

Keywords:

Activity Tolerance, Anxiety Disorders, Biopsychosocial Model, Chronic Dyspnea, Multimorbidity, Pulmonary Rehabilitation, Self-Management, Structured Diagnostic Strategy

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References

  1. Johnson MJ, Currow DC, Booth S. Prevalence and assessment of breathlessness in the clinical setting. Expert Rev Respir Med.
  2. ;8(2):151-61.
  3. Baxter N. Breathlessness in the primary care setting. Curr Opin Support Palliat Care. 2017;11(3):152-8.
  4. Ferreira DH, Kochovska S, Brunelli VN, Currow DC. Understanding persistent breathlessness: impact on patients and optimal
  5. approaches to symptomatic reduction – an overview. Expert Rev Respir Med. 2023;17(5):365-79.
  6. Johnson MJ, Yorke J, Hansen-Flaschen J, Lansing R, Ekström M, Similowski T, et al. Towards an expert consensus to delineate
  7. a clinical syndrome of chronic breathlessness. Eur Respir J. 2017;49(5):1602277.
  8. Sandberg J, Olsson M, Ekström M. Underlying conditions contributing to breathlessness in the population. Curr Opin Support
  9. Palliat Care. 2021;15(4):219-25.
  10. Hayen A, Herigstad M, Pattinson KTS. Understanding dyspnea as a complex individual experience. Maturitas. 2013;76(1):45-50.
  11. Berliner D, Schneider N, Welte T, Bauersachs J. The differential diagnosis of dyspnea. Dtsch Arztebl Int. 9 2016; 9;113(49):834-45
  12. IPCRG. Desktop Helper No.17 - Breathlessness in adults: A practical guide for primary care clinicians - online version. Lien: https://www.ipcrg.org/IPCRG_DTH17_Online (Dernière visite: 29 avril 2026).
  13. Booth S, Johnson MJ. Improving the quality of life of people with advanced respiratory disease and severe breathlessness. Breathe.
  14. ;15(3):198-215.
  15. Spathis A, Booth S, Moffat C, Hurst R, Ryan R, Chin C, et al. The breathing, thinking, functioning clinical model: a proposal to
  16. facilitate evidence-based breathlessness management in chronic respiratory disease. npj Prim Care Resp Med. 2017;27(1):27.
  17. Poulos LM, Ampon RD, Currow DC, Marks GB, Toelle BG, Reddel HK. Prevalence and burden of breathlessness in Australian adults:
  18. The national breathlessness survey—a cross-sectional web-based population survey. Respirology. 2021;26(8):768-75.
  19. EkströmM, Sundh J, Andersson A, Angerås O, Blomberg A, Börjesson M, et al. Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women. Respir Res. 2024;25(1):127.
  20. Sandberg J, Ekström M, Börjesson M, Bergström G, Rosengren A, Angerås O, et al. Underlying contributing conditions to
  21. breathlessness among middle-aged individuals in the general population: a cross-sectional study. BMJ Open Resp Res. 2020;7(1).
  22. Santos M, Kitzman DW, Matsushita K, Loehr L, Sueta CA, Shah AM. Prognostic importance of dyspnea for cardiovascular outcomes
  23. and mortality in persons without prevalent cardiopulmonary disease: The atherosclerosis risk in communities study. PLoS One.
  24. ;11(10):e0165111.
  25. Nishimura K, Izumi T, Tsukino M, Oga T. Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD. Chest. 2002;121(5):1434-40.
  26. Sandberg J, Engström G, Ekström M. Breathlessness and incidence of COPD, cardiac events and all-cause mortality: A 44-year follow-up from middle age throughout life. PLoS One. 2019;14(3):e0214083.
  27. Sunjaya A, Martin A, Arnott C, Jenkins C. Management of chronicbreathlessness in primary care: what do GPs, non-GP specialists,
  28. and allied health professionals think? Aust J Prim Health. 2023;29(4):375-84.
  29. Doe G, Clanchy J, Wathall S, Chantrell S, Edwards S, Baxter N, et al. Feasibility study of a multicentre cluster randomised control trial
  30. to investigate the clinical and cost-effectiveness of a structured diagnostic pathway in primary care for chronic breathlessness:
  31. protocol paper. BMJ Open. 2021;11(11):e057362.
  32. Doe G, Clanchy J, Wathall S, Barber S, Edwards SA, Evans H, et al. Investigating a structured diagnostic approach for chronic
  33. breathlessness in primary care: a mixed-methods feasibility cluster randomised controlled trial. BMJ Open Resp Res.
  34. ;12(1):e002716.
  35. Bausewein C, Booth S, Gysels M, Higginson I. Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev. 2008;(2):CD005623.
  36. WHO-ICRC Basic emergency care: Approach to the acutely ill and injured. Lien: https://www.who.int/publications/i/
  37. item/9789241513081 (Dernière visite: 29 avril 2026).
  38. Parshall MB, Schwartzstein RM, Adams L, Banzett RB, Manning HL, Bourbeau J, et al. An official American thoracic society statement:
  39. Update on the mechanisms, assessment, and management of dyspnea. Am J Respir Crit Care Med. 2012;185(4):435-52.
  40. Ramon MA, Ter Riet G, Carsin AE, Gimeno-Santos E, Agustí A, Antó JM, et al. The dyspnoea–inactivity vicious circle in COPD:
  41. development and external validation of a conceptual model. Eur Respir J. 2018;52(3):1800079.
  42. Currow DC, Dal Grande E, Ferreira D, Johnson MJ, McCaffrey N, Ekström M. Chronic breathlessness associated with poorer physical
  43. and mental health-related quality of life (SF-12) across all adult age groups. Thorax. 2017;72(12):1151-3.
  44. Lunn S, Dharmagunawardena R, Lander M, Sweeney J. It's hard to talk about breathlessness: A unique insight from respiratory
  45. trainees. Clin Med (Lond). 2019;19(4):344-347.
  46. England NHS. Adult breathlessness pathway (pre-diagnosis): diagnostic pathway support tool. Lien: https://www.england.
  47. nhs.uk/long-read/adult-breathlessness-pathway-pre-diagnosis-diagnostic-pathway-support-tool/ (Dernière visite: 29 avril 2026).
  48. IPCRG. «How are you feeling right now?» Cartoons for emotional self-assessment for people with chronic respiratory diseases. Lien:
  49. https://www.ipcrg.org/emotions (Dernière visite: 29 avril 2026).
  50. Gataa R, Ajmi TN, Bougmiza I, Mtiraoui A. Morbidity patterns in general practice settings of the province of Sousse, Tunisia. Pan Afr
  51. Med J. 2009;3:11.
  52. Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest. 1988;93(3):580-6.
  53. Smoking history. Lien: https://www.ipcrg.org/IPCRG_DTH17_Online#Smoking (Dernière visite: 29 avril 2026).
  54. Medical Research Council dyspnoea (breathlessness) scale | My Lungs My Life. Lien: https://www.mylungsmylife.org/topics/
  55. group-1/symptoms-of-copd/medical-research-council-dyspnoea-scale/ (Dernière visite: 29 avril 2026).
  56. BTS quality improvement tool for smoking cessation. Lien: https://www.brit-thoracic.org.uk/media/70094/appendix-1-patient-
  57. record.pdf (Dernière visite: 29 avril 2026).
  58. Smoking Pack Years. Home. Lien: https://www.smokingpackyears.com/ (Dernière visite: 29 avril 2026).
  59. Patient Health Questionnaire-4 (PHQ-4) | QxMD. Lien: https://qxmd.com/calculate/calculator_476/patient-health-questionnaire-
  60. -phq-4 (Dernière visite: 29 avril 2026).
  61. Global physical activity questionnaire (GPAQ). Lien: https://www.who.int/publications/m/item/global-physical-activity-
  62. questionnaire (Dernière visite: 29 avril 2026).
  63. General practice physical activity questionnaire (GPPAQ). Lien: https://www.gov.uk/government/publications/general-practice-
  64. physical-activity-questionnaire-gppaq (Dernière visite: 29 avril 2026).
  65. Nijmegen-Questionnaire.pdf. Lien: https://bronchiectasis.com.au/wp-content/uploads/2015/09/BW-Nijmegen-Questionnaire.pdf
  66. (Dernière visite: 29 avril 2026).
  67. The BROMPTON BPAT (breathing pattern assessment tool). Lien: https://physiotherapyforbpd.org.uk/BPAT.pdf (Dernière visite: 29
  68. avril 2026).
  69. Dependence on smoking. Lien: https://www.ncsct.co.uk/publications/ dependence-on-smoking (Dernière visite: 29 avril 2026).
  70. IPCRG. Desktop Helper No. 14 - Quick guide to spirometry. Lien: https://www.ipcrg.org/DTH14 (Dernière visite: 29 avril 2026).
  71. The official STOP-Bang questionnaire website. Lien: http://www. stopbang.ca/osa/screening.php (Dernière visite: 29 avril 2026).
  72. Epworth sleepiness scale | Asthma + Lung UK. Lien: https://www. asthmaandlung.org.uk/conditions/obstructive-sleep-apnoea-osa/
  73. epworth-sleepiness-scale (Dernière visite: 29 avril 2026).
  74. Patient health questionnaire (PHQ) screeners. Lien: https://www.phqscreeners.com/select-screener/ (Dernière visite: 29 avril 2026).
  75. van Dixhoorn J, Folgering H. The Nijmegen Questionnaire and dysfunctional breathing. ERJ Open Res. 2015;1(1):00001-2015.
  76. Self-management strategies that may help reduce sense ofbreathlessness. Lien: https://www.ipcrg.org/IPCRG_DTH17_
  77. Online#Selfmanagement (Dernière visite: 29 avril 2026).
  78. Singh B, Olds T, Curtis R, Dumuid D, Virgara R, Watson A, et al. Effectiveness of physical activity interventions for improving
  79. depression, anxiety and distress: an overview of systematic reviews. Br J Sports Med. 2023;57(18):1203-9.
  80. Clark J, Salins N, Pearson M, Sherigar M, Rao S, Williams S, et al. Implementing breathlessness self-management in low- and middle-
  81. income countries: co-design of breathlessness self-management resources for use in India. NPJ Prim Care Respir Med. 2025 Nov
  82. ;35:55.
  83. Semlitsch T, Stigler FL, Jeitler K, Horvath K, Siebenhofer A. Management of overweight and obesity in primary care—A
  84. systematic overview of international evidence-based guidelines. Obes Rev. 2019;20(9):1218-30.
  85. Ekström M, Ferreira D, Chang S, Louw S, Johnson MJ, Eckert DJ, et al. Effect of regular, low-dose, extended-release morphine on
  86. chronic breathlessness in chronic obstructive pulmonary disease: The BEAMS randomized clinical trial. JAMA. 22 2022;328(20):2022.
  87. Currow DC, Ekström M, Louw S, Hill J, Fazekas B, Clark K, et al. Sertraline in symptomatic chronic breathlessness: a double blind,
  88. randomised trial. Eur Respir J. 2019;53(1):1801270.
  89. Simon ST, Higginson IJ, Booth S, Harding R, Weingärtner V, Bausewein C. Benzodiazepines for the relief of breathlessness
  90. in advanced malignant and non-malignant diseases in adults.Cochrane Database Syst Rev. 2016;10(10):CD007354.
  91. Van Schayck OCP, Williams S, Barchilon V, Baxter N, Jawad M, Katsaounou PA, et al. Treating tobacco dependence: guidance for
  92. primary care on life-saving interventions. Position statement of the IPCRG. npj Prim Care Resp Med. 2017;27(1):38.
  93. Hardinge M, Annandale J, Bourne S, Cooper B, Evans A, Freeman D, et al. British thoracic society guidelines for home oxygen use in
  94. adults: accredited by NICE. Thorax. 2015;70(Suppl 1):i1-43.
  95. Abernethy AP, McDonald CF, Frith PA, Clark K, Herndon JE, Marcello J, et al. Effect of palliative oxygen versus room air in relief of
  96. breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. The Lancet. 2010;376(9743):784-93.
  97. Holland AE, Hill CJ, Jones AY, McDonald CF. Breathing exercises for chronic obstructive pulmonary disease. Cochrane Database Syst
  98. Rev. 2012;10(10):CD008250.
  99. Luckett T, Phillips J, Johnson MJ, Farquhar M, Swan F, Assen T, et al. Contributions of a hand-held fan to self-management of chronic
  100. breathlessness. Eur Respir J. 2017;50(2):1700262.
  101. Using a handheld fan to reduce breathlessness. Lien: https://www. youtube.com/watch?v=y5tBC5R8DYs (Dernière visite: 29 avril
  102. .
  103. COPD magazine. Lien: https://www.ipcrg.org/copdmagazine(Dernière visite: 29 avril 2026).
  104. Breaking the dyspnea cycle with pursed lip breathing. Lien: https://www.youtube.com/watch?v=Q8GH7iKB7N4 (Dernière visite: 29
  105. avril 2026).
  106. Welcome to supporting breathlessness. Lien: https://supporting- breathlessness.org.uk/ (Dernière visite: 29 avril 2026).
  107. IPCRG. Desktop Helper No.12 - COPD and Mental Health: Holistic and Practical Guidance for Primary Care - online version. Lien:
  108. https://www.ipcrg.org/DTH12 (Dernière visite: 25 avril 2026).
  109. Ben Romdhane H, Tlili F, Skhiri A, Zaman S, Phillimore P. Health system challenges of NCDs in Tunisia. Int J Public Health. 2014
  110. Nov;60 Suppl 1:S39-46.
  111. Hidouri S, Kamoun H, Salah S, Jellad A, Ben Saad H. Key guidelines for responding to reviewers. F1000Res 2024, 13:921.
  112. Dergaa I, Zakhama L, Dziri C, Ben Saad H. Enhancing scholarly discourse in the age of artificial intelligence: A guided approach to
  113. effective peer review process. Tunis Med. 2023;101(10):721-6.