Mapping the Mobile Health Applications Landscape: A Cluster-Based Systematic Review

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Published Oct 11, 2026
https://doi.org/10.62438/tunismed.v104i09.6755
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Vol. 104 No. 09 (2026): Tunis Med Sept 2026

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Fatima Ezzahra Yakoubi
Research Laboratory in Management, Digital, Innovation and Logistics (Madilog), Ibn Zohr University, Postal Code 80000, Agadir, Morocco
Hanan Belkasmi
Research Laboratory in Management, Digital, Innovation and Logistics (Madilog), Ibn Zohr University, Postal Code 80000, Agadir, Morocco
Aziz Hantem
Research Laboratory in Management, Digital, Innovation and Logistics (Madilog), Ibn Zohr University, Postal Code 80000, Agadir, Morocco.

Abstract

Introduction-Aim: Mobile health applications (MHAs) have become essential components of modern healthcare systems worldwide. Despite their growing adoption, a comprehensive global synthesis integrating clinical outcomes, adoption factors, and regional distribution of MHA research remains lacking. This review provides a systematic, cluster-based global perspective on MHAs by examining research trends, typologies, and regional disparities across peer-reviewed literature published from 2015 to 2023.
Methods: A systematic literature review was conducted following PRISMA guidelines. Articles were retrieved from Scopus, Web of Science, and PubMed using search terms including "mobile health," "mHealth," and "mobile health applications," restricted to peer-reviewed English-language
publications. After screening 1,430 identified records, 229 studies were included in the final synthesis. Thematic cluster analysis was performed using VOSviewer to identify and visualize key research clusters.
Results: Three main thematic clusters were identified: (1) Clinical interventions and outcomes, demonstrating positive effects of MHAs on chronic disease management, patient adherence, and healthcare costs, notably in diabetes, hypertension, and asthma; (2) Psychological and social factors, highlighting the critical role of user-centered design, perceived usefulness (TAM), and social influence (UTAUT) in driving MHA adoption; and (3) Technology and development, addressing interoperability challenges, data security concerns, and device accessibility. MHA typologies span clinical diagnostics, disease management, health promotion, telemedicine, and clinical reference tools. The United States leads in research output, followed by Europe and Asia, while Latin America and Africa remain significantly underrepresented.
Conclusion: MHAs hold significant potential to bridge global healthcare gaps, particularly in resource-limited settings. Standardizing clinical trial protocols, improving user-centered design, strengthening data security, and fostering research in underrepresented regions are critical priorities for researchers, developers, and policymakers advancing equitable healthcare delivery through mobile technologies.

Keywords:

mobile health applications, healthcare delivery, chronic disease management, systematic review, technology acceptance, healthcare outcomes

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References

  1. World Health Organization. mHealth: new horizons for health through mobile technologies: second global survey on eHealth
  2. [Internet]. 2011 [cited 2025 Jul 24];Global observatory for eHealth Series, 3. Available from: https://iris.who.int/handle/10665/44607
  3. Halit Eren JGW. Telehealth and Mobile Health: The E-Medicine, E-Health, M-Health, Telemedicine, and Telehealth Handbook,
  4. Volume II. Mob Health. 2016;2.
  5. Free C, Phillips G, Galli L, Watson L, Felix L, Edwards P, et al. The Effectiveness of Mobile-Health Technology-Based Health Behaviour
  6. Change or Disease Management Interventions for Health Care Consumers: A Systematic Review. Cornford T, editor. PLoS Med.
  7. Jan 15;10(1):e1001362. doi:10.1371/journal.pmed.1001362
  8. World Health Organization. mHealth: Use of appropriate digital technologies for public health. 2017. Report No.
  9. Free C, Phillips G, Felix L, Galli L, Patel V, Edwards P. The effectiveness of M-health technologies for improving health and health services: a systematic review protocol. BMC Res Notes. 2010 Dec;3(1):250. doi:10.1186/1756-0500-3-250
  10. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for
  11. reporting systematic reviews. BMJ. 2021 Mar 29;n71. doi:10.1136/ bmj.n71
  12. Van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010
  13. Aug;84(2):523–38. doi:10.1007/s11192-009-0146-3
  14. Eberle C, Loehnert M, Stichling S. Effectivness of specific mobile health applications (mHealth-apps) in gestational diabtetes
  15. mellitus: a systematic review. BMC Pregnancy Childbirth. 2021 Dec;21(1):808. doi:10.1186/s12884-021-04274-7
  16. Prinja S, Gupta A, Bahuguna P, Nimesh R. Cost analysis of implementing mHealth intervention for maternal, newborn &
  17. child health care through community health workers: assessment of ReMIND program in Uttar Pradesh, India. BMC Pregnancy
  18. Childbirth. 2018 Dec;18(1):390. doi:10.1186/s12884-018-2019-3
  19. Gong K, Yan YL, Li Y, Du J, Wang J, Han Y, et al. Mobile health applications for the management of primary hypertension: A
  20. multicenter, randomized, controlled trial. Medicine (Baltimore). 2020 Apr;99(16):e19715. doi:10.1097/MD.0000000000019715
  21. Lee K, Kwon H, Lee B, Lee G, Lee JH, Park YR, et al. Effect of self- monitoring on long-term patient engagement with mobile
  22. health applications. Serrano K, editor. PLOS ONE. 2018 Jul 26;13(7):e0201166. doi:10.1371/journal.pone.0201166
  23. Al Ansari FS, Alfayez A, Alsalman D, Alanezi F, Alhodaib H, Al-Rayes S, et al. Using mobile health applications to enhance physical activity in Saudi Arabia: a cross-sectional study on users’ perceptions. Int Health. 2023 Jan 3;15(1):47–55. doi:10.1093/inthealth/ihac008
  24. Tajudeen FP, Bahar N, Tan MP, Peer Mustafa MB, Saedon NI, Jesudass J. Understanding User Requirements for a Senior-Friendly
  25. Mobile Health Application. Geriatrics. 2022 Oct 1;7(5):110. doi:10.3390/geriatrics7050110
  26. Alsswey A, Naufal I, Bervell B. Investigating the Acceptance of Mobile Health Application User Interface Cultural-Based Design
  27. to Assist Arab Elderly Users. Int J Adv Comput Sci Appl. 2018;9(8). doi:10.14569/IJACSA.2018.090819
  28. Li C, Neugroschl J, Zhu CW, Aloysi A, Schimming CA, Cai D, et al. Design Considerations for Mobile Health Applications Targeting
  29. Older Adults. J Alzheimers Dis. 2021 Jan 5;79(1):1–8. doi:10.3233/ JAD-200485
  30. Wang C, Qi H. Influencing Factors of Acceptance and Use Behavior of Mobile Health Application Users: Systematic Review. Healthcare. 2021 Mar 22;9(3):357. doi:10.3390/healthcare9030357
  31. Lobach DF, Boxwala A, Kashyap N, Heaney-Huls K, Chiao AB, Rafter T, et al. Integrating a Patient Engagement App into an
  32. Electronic Health Record-Enabled Workflow Using Interoperability Standards. Appl Clin Inform. 2022 Oct;13(05):1163–71.
  33. doi:10.1055/s-0042-1758736
  34. Papageorgiou A, Strigkos M, Politou E, Alepis E, Solanas A, Patsakis C. Security and Privacy Analysis of Mobile Health Applications:
  35. The Alarming State of Practice. IEEE Access. 2018;6:9390–403. doi:10.1109/ACCESS.2018.2799522
  36. Hantem A, Emzi K, Youssoufi N, Emzi K, Mkik M, Outaaza K. Factors Influencing Patient Satisfaction with the Use of Teleconsultation
  37. in Morocco. In: Lect. Notes Networks Syst. Springer Science and Business Media Deutschland GmbH; 2024. p. 441–51.
  38. doi:10.1007/978-981-97-6588-1_33
  39. Franc S, Hanaire H, Benhamou PY, Schaepelynck P, Catargi B, Farret A, et al. DIABEO System Combining a Mobile App Software With
  40. and Without Telemonitoring Versus Standard Care: A Randomized Controlled Trial in Diabetes Patients Poorly Controlled with a
  41. Basal-Bolus Insulin Regimen. Diabetes Technol Ther. 2020 Dec 1;22(12):904–11. doi:10.1089/dia.2020.0021