Endothelial Lipase RS3744843 Polymorphism and Lipid Profile in Bechet’s Disease Patients

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Published Apr 12, 2026
https://doi.org/10.62438/tunismed.v104i03.6217
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Vol. 104 No. 03 (2026): Tunis Med Mar 2026

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Rihab Makhlouf
Department of Clinical Chemistry Laboratory, Habib Bourguiba Hospital, Sfax, Research Laboratory LR19ES13 of Molecular Bases of Human Diseases, Faculty of Medicine of Sfax, Sfax, Tunisia
Meriam Messedi
Research Laboratory LR19ES13 of Molecular Bases of Human Diseases, Faculty of Medicine of Sfax, Sfax, Tunisia
Mouna Snoussi
Department of Internal medicine, Hedi Chaker Hospital, Sfax, Tunisia
Khansa Chaabouni
Department of Clinical Chemistry Laboratory, Habib Bourguiba Hospital, Sfax, Research Laboratory LR19ES13 of Molecular Bases of Human Diseases, Faculty of Medicine of Sfax, Sfax, Tunisia
Bochra Ben Rhouma
Department of Human Molecular Genetic Laboratory, Faculty of Medicine of Sfax, Sfax, Tunisia
Zouhair Bahloul
Department of Internal medicine, Hedi Chaker Hospital, Sfax, Research Laboratory LR19ES13 of Molecular Bases of Human Diseases, Faculty of Medicine of Sfax, Sfax, Tunisia
Fatma Makni Ayadi
Department of Clinical Chemistry Laboratory, Habib Bourguiba Hospital, Sfax, Research Laboratory LR19ES13 of Molecular Bases of Human Diseases, Faculty of Medicine of Sfax, Sfax, Tunisia
Kamel Jamoussi
Department of Clinical Chemistry Laboratory, Hedi Chaker Hospital, Sfax, Research Laboratory LR19ES13 of Molecular Bases of Human Diseases, Faculty of Medicine of Sfax, Sfax, Tunisia

Abstract

Introducrion: Endothelial lipase gene (LIPG) is implicated in lipid metabolism particularly HDL-C metabolism and in inflammation. Several identified
single nucleotide polymorphisms (SNPs) of LIPG were associated with lipoprotein and apolipoprotein metabolism. The implication of LIPG in a chronic inflammation due to multisystemic vasculitis has not been elucidated.
Objective: To assess the association between EL 2037 T/C (rs3744843) polymorphism and alterations in lipid profiles and biomarkers of endothelial
dysfunction (such as high-sensitivity C-reactive protein and Homocysteine) in Tunisian patients with Behçet disease (BD).
Methods: A case-control study including BD patients with controls was performed. Lipid profile, high-sensitivity C-reactive protein and homocysteine
were assessed to all subjects. The polymerase chain reaction-restriction fragment length polymorphism method was used.
Results: We included 116 BD patients and 102 healthy controls in this study. Overall, HDL-C levels were significantly lower in patients. While
genotype and allele distributions did not differ significantly between groups, a distinct pattern emerged in HDL-C levels. In healthy controls, C allele
carriers had higher HDL-C concentrations compared to TT individuals. In contrast, BD patients carrying the C allele had significantly lower HDL-C levels, particularly in the presence of hyperhomocysteinemia or a disease activity score >5.
Conclusion: EL 2037 T/C polymorphism was correlated with lipid levels in BD patients and controls. No association was demonstrated between this polymorphism and BD.

Keywords:

Endothelial Lipase, Polymorphism, Lipid profile, Inflammation, Behçet’s disease, Multisystemic vasculitis

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