Assessment of liver fibrosis in Chronic hepatitis B: Performance of hematological parameters

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Published Apr 12, 2026
https://doi.org/10.62438/tunismed.v104i03.5992
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Vol. 104 No. 03 (2026): Tunis Med Mar 2026

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Asma Ben Mohamed
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia
Sahar Chtioui
Departement of gastroenterology,La Rabta hospital,Tunis, faculty of medicine of Tunis, University of Tunis Manar, Tunisia
Manel Yakoubi
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia
Ghada Gharbi
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia
Ikbel Ghachem
Medical analysis laboratory,Mohamed Taher Maamouri hospital,Nabeul, Faculty of medicine of Tunis, University of Tunis Manar, Tunisia
Moufida Mahmoudi
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia
Amal Khsiba
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia
Mouna Medhioub
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia
Mohamed Lamine Hamzaoui
Departement of gastroenterology, Mohamed Taher Maamouri hospital, Nabeul, Faculty of medicine of Tunis,University of Tunis Manar, Tunisia

Abstract

Introduction: Hepatitis B is a major global health problem. Assessment of liver fibrosis is important for treatment decision. Liver biopsy (LB) represents the "Gold Standard" in the assessment of fibrosis. Several parameters have been identified for predicting the development and progression of liver disease; among them, hematological parameters.
The aim of our study was to assess the performance of these hematological parameters in the assessment of fibrosis in chronic hepatitis B.
Methods: We conducted a retrospective study involving all patients with chronic hepatitis B managed in Gastroenterology department of Mohamed Taher Maamouri hospital during the period from January 2013 to December 2022, who underwent a liver biopsy and routine laboratory tests.
According to the METAVIR scoring system, patients were divided into two groups: patients without significant fibrosis (F0, F1) and patients with
significant fibrosis (F2, F3, F4). The predictive accuracy for liver fibrosis was assessed by receiver operating characteristics (ROC) analysis.
Results: A total of 119 patients were included. Liver biopsy revealed significant fibrosis in 20.2% of the patients. The mean platelet count was
significantly lower in patients with significant fibrosis, as compared to patients with non-significant fibrosis (p< 0.001). The AUROC of RDW was 0.857 with a cut-off value of 41.8 FL (sensitivity 88.9%; specificity 70.9%; Positive and negative predictive values 50% and 95.1% respectively).
Conclusion: Blood count parameters are non-invasive markers of liver fibrosis in patients with chronic hepatitis B. Thus, significant fibrosis can ...( abstract truncated at 250 words)

Keywords:

Chronic hepatitis B, Evaluation, Liver fibrosis, Biopsy, Blood count

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