Tunisian recommendations for the diagnosis and evaluation of Spondyloarthritis
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Abstract
Advancements in understanding SpA have greatly improved patient quality of life through early detection and effective treatment. However, non-specialist physicians often face challenges in identifying the early symptoms of SpA.
Aim: This study aims to assist healthcare practitioners in the early detection of SpA and to streamline management strategies by employing a standardized assessment protocol for adult patients with SpA. LITAR collaborated with fifteen rheumatologists to adhere to INEAS guidelines. The team created a comprehensive repository based on seven PICO questions and their answers. To create this repository, the team combined local Tunisian data and insights from relevant literature sources using a synthesis method.
Results: This research culminated in the formulation of twelve evidence-based recommendations for best practices, encompassing three critical domains. Firstly, it addresses the clinical indications and signs that should alert primary care physicians to consider a SpA diagnosis and promptly refer patients to rheumatologists. Secondly, it outlines the diagnostic procedures involved in confirming SpA. Lastly, it presents standardized methods for evaluating and monitoring the progression of SpA. To ensure the robustness of these recommendations, an independent reading group of 19 experts from various related specialties validated them. Subsequently, a panel of 54 Tunisian rheumatologists practicing in diverse sectors, including public health, academia, and the private sector, evaluated the strength of these recommendations. The strength ratings ranged from 8 to 9, with a degree of agreement spanning from 72% to 100%.
Conclusion: This guideline, developed with the support of LITAR and accredited by INEAS,...(abstract truncated at 250 words)
Keywords:
Spondylarthritis, recommandations, Tunisia, diagnosis referral and consultation, diagnostic imaging##plugins.themes.academic_pro.article.details##

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
- Rudwaleit M, van der Heijde D, Landewé R, Akkoc N, Brandt J, Chou CT, et al. The Assessment of SpondyloArthritis International Society classification criteria for peripheral spondyloarthritis and for spondyloarthritis in general. Ann Rheum Dis 2011;70:25–31.
- Claudepierre P, Wendling D, Breban M, Goupillle P, Dougados M. Ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, or spondylarthritis: what's in a name? Joint Bone Spine. 2012;79(6):534-5.
- Slimani S, Hamdi W, Nassar K, Kalla AA. Spondyloarthritis in North Africa: an update. Clin Rheumatol. 2021;40(9):3401-3410. doi: 10.1007/s10067-021-05630-w. Epub 2021 Feb 9.
- Younes M, Jalled A, Aydi Z, Zrour S, Korbaa W, Ben Salah Z et al. Impact socioéconomique de la spondylarthrite ankylosante en Tunisie. Rev Rhum. 2010;77 :49-54. doi:10.1016/j.jbspin.2009.11.007
- Younes M, Jalled A, Aydi Z, Younes K, Jguirim M, Zrour S et al. Qualité de vie au cours de la spondylarthrite ankylosante. Tunisie médicale. 2011;98(3):374-8.
- Poddubnyy D, van Tubergen A, Landewé R, Sieper J, van der Heijde D. Development of an ASAS-endorsed recommendation for the early referral of patients with a suspicion of axial spondyloarthritis. Ann Rheum Dis. 2015;74(8):1483-7. doi: 10.1136/annrheumdis-2014-207151
- Forster D, Warburton L, Flynn N. Diagnosis and management of spondyloarthritis in the over-16s: NICE guideline. British Journal of General Practice. 2018;68 (672): 346-7. DOI: https://doi.org/10.3399/bjgp18X697865
- Van der Heijde D, Ramiro S, Landewe R, Baraliakos X, Van den Bosch F, Sepriano A, et al. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017;76:978–91.
- Wendling D, Hecquet S, Fogeld O,Letarouillye J-G,Verhoevena F, Pham T, et al. Actualisation 2022 des recommandations de la Société francaise de rhumatologie (SFR) pour la prise en charge en pratique courante des malades atteints de spondyloarthrite, incluant le rhumatisme psoriasique. Rev Rhumatisme. 2022;89:210–222.
- Ward MM, Deodhar A, Gensler LS. Update of the American College of Rheumatology/Spondylitis association of America/Spondyloarthritis research and treatment network recommendations for the treatment of ankylosing spondylitis and Nonradiographic axial spondyloarthritis. Arthritis & rheumatology. 2019Oct;71(10):1599-1613.
- Baccouche K, Mahmoud I, Manaa M, Gharsallah I, Testouri N, Maatallah K et al. Recommandations Tunisiennes de bonnes pratiques pour la prise en charge des Spondylarthrites: Méthodologie. Tunis Med. 2025;103(1):18-21. DOI: 10.62438/tunismed.v103i1.5550
- Guide Méthodologique National d’élaboration de RBP dans le domaine de la santé du Ministère de la Santé de la République Tunisienne. 2012.
- Schardt C, Adams M B, Owens T, Keitz S, Fontelo P. Utilization of the PICO framework to improve searching PubMed for clinical questions. BMC Med Inform Decis Mak. 2007, 7:16. Published online 2007 Jun 15. doi: 10.1186/1472-6947-7-16
- Haute Autorité de Santé. Guide d’analyse de la littérature et gradation des recommandations. Saint-Denis La Plaine: HAS; 2000.
- Poddubnyy D, Vahldiek J, Spiller I, Buss B, Listing J, Rudwaleit M, et al. Evaluation of 2 screening strategies for early identification of patients with axial spondyloarthritis in primary care. J Rheumatol. 2016;43(3):607-17. doi: 10.3899/jrheum.150721
- Braun A, Saracbasi E, Grifka J, Schnitker J, Braun J. Identifying patients with axial spondyloarthritis in primary care: how useful are items indicative of inflammatory back pain? Ann Rheum Dis. 2011;70(10):1782-7. doi: 10.1136/ard.2011.151167.
- Sieper J, Srinivasan S, Zamani O, Mielants H, Choquette D, Pavelka K, et al. Comparison of two referral strategies for diagnosis of axial spondyloarthritis: the Recognising and Diagnosing Ankylosing Spondylitis Reliably (RADAR) study. Ann Rheum Dis. 2013; 72(10):1621-7. doi: 10.1136/annrheumdis-2012-201777.
- Mok CC, Tam LS, Leung MH, Ying KY, To CH, Lee KL, et al. Referral strategy for early recognition of axial spondyloarthritis: consensus recommendations from the Hong Kong Society of Rheumatology. Int J Rheum Dis. 2013;16(5):500-8. doi: 10.1111/1756-185X.12161.
- Arnbak B , Hendricks O ,Hørslev-Petersen K , Jurik AG , Pedersen SJ , Østergaad M , et al. The discriminative value of inflammatory back pain in patients with persistent low back pain. Scand J Rheumatol . 2016 Jul;45(4):321-8. doi: 10.3109/03009742.2015.1105289. Epub 2016 Mar 16.
- Carron P, Van Praet L, Van den Bosch F. Peripheral manifestations in spondyloarthritis: relevance for diagnosis, classification and follow-up. Curr Opin Rheumatol. 2012 Jul;24(4):370-4. doi: 10.1097/BOR.0b013e32835448de.
- Ozgocmen S, Asim Khan M. Current Concept of Spondyloarthritis: Special Emphasison Early Referral and Diagnosis. Curr Rheumatol Rep. 2012;14:409–14. DOI 10.1007/s11926-012-0274-2
- Tomero E, Mulero J, de Miguel E, Fernández-Espartero C, Gobbo M, Descalzo M A, et al. Performance of the Assessment of Spondyloarthritis International Society criteria for the classification of spondyloarthritis in early spondyloarthritis clinics participating in the ESPERANZA programme. Rheumatology, 2014;53(2):353–60. https://doi.org/10.1093/rheumatology/ket359
- Sanz J, Roura JX, Seoane-Mato D, Montoro M, Gomollón F; Grupo de Trabajo del proyecto PIIASER. Screening of Inflammatory Bowel Disease and Spondyloarthritis for Referring Patients Between Rheumatology and Gastroenterology. Reumatol Clin. 2018; 14(2):68-74. doi: 10.1016/j.reuma.2017.07.001. Epub 2017 Aug 4.
- Iragorri N, Hazlewood G, Manns B. Psoriatic arthritis screening: a systematic review and meta-analysis. Rheumatology. 2019; 58: 692-707. doi:10.1093/rheumatology/key314
- Haroon M, O’Rourke M, Ramasamy P, Murphy C. A novel evidence-based detection of undiagnosed spondyloarthritis in patients presenting with acute anterior uveitis: the DUET (Dublin UveitisEvaluation Tool). Ann Rheum Dis. 2014;0:1–6. doi:10.1136/annrheumdis-2014-205358
- Fitz Gerald O, Forster D, Warburton L, O’Flynn N. Diagnosis and management of spondyloarthritis in the over-16s: NICE guideline. Br J Gen Pract. 2018 Jul;68(672):346-347.
- Van den Berg R, Lenczner G, Feydy A, Van der Heijde D, Reijnierse M, Saraux A, et al. Agreement between clinical practice and trained central reading in reading of sacroiliac joints on plain pelvic radiographs. Results from the DESIR cohort. Arthritis Rheumatol. 2014;66(9):2403-11.
- Rudwaleit M, Van der Heijde D, Landewe R, Listing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis.2009; 68(6):777–83. doi:10.1136/ard.2009.108233
- Dougados M, d’ Agostino MA, Benessiano J, Berenbaum F, Breban M, Claudepierre P, et al. The DESIR cohort: A 10-year follow-up of early inflammatory back pain in France: Study design and baseline characteristics of the 708 recruited patients. Joint Bone Spine.2011;78(6), 598–603
- Van den Berg R, De Hooge M, Rudwaleit M, Sieper J, Van Gaalen F, Reijnierse M, et al. ASAS modification of the Berlin algorithm for diagnosing axial spondyloarthritis: results from the SPondyloArthritis Caught Early (SPACE)-cohort and from the Assessment of SpondyloArthritis international Society (ASAS)-cohort. Ann Rheum Dis.. 2012.72(10): 1646–53
- Molto A, Paternotte S, Comet D, Thibout E, Rudwaleit M, Claudepierre P, et al. Performances of the Assessment of SpondyloArthritis International Society Axial Spondyloarthritis Criteria for Diagnostic and Classification Purposes in Patients Visiting a Rheumatologist Because of Chronic Back Pain: Results From a Multicenter, Cross-Sectional Study. Arthritis Care & Research.2013;65(9):1472–81
- Battistone MJ, Manaster BJ, Reda DJ, Clegg DO. Radiographic diagnosis of sacroiliitis--are sacroiliac views really better? J Rheumatol. 1998;25(12):2395-401.
- Omar A, Sari I, Bedaiwi M, Salonen D, Haroon N, Inman RD. Analysis of dedicated sacroiliac views to improve reliability of conventional pelvic radiographs. Rheumatology (Oxford).2017;56(10):1740-5
- van Tubergen A, Heuft-Dorenbosch L, Schulpen G, Landewé R, Wijers R, van der Heijde D et al. Radiographic assessment of sacroiliitis by radiologists and rheumatologists: does training improve quality? Ann Rheum Dis 2003;62:519–25
- Sudoł-Szopińska I, Jurik AG, Eshed I, Lennart J, Grainger A, Østergaard M, et al. Recommendations of the ESSR Arthritis Subcommittee for the Use of Magnetic Resonance Imaging in Musculoskeletal Rheumatic Diseases. Semin Musculoskelet Radiol. 2015;19(4):396-411.
- Mandl P, Navarro-Compán V, Terslev L, Aegerter P, van der Heijde D, D'Agostino MA, et al ; European League Against Rheumatism (EULAR). EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice. Ann Rheum Dis. 2015;74(7):1327-39. doi: 10.1136/annrheumdis-2014-206971. Epub 2015 Apr 2.
- Lambert RG, Bakker PA, van der Heijde D, Weber U, Rudwaleit M, Hermann KG, et al. Defining active sacroiliitis on MRI for classification of axial spondyloarthritis: update by the ASAS MRI working group. Ann Rheum Dis. 2016;75(11):1958-1963. doi: 10.1136/annrheumdis-2015-208642. Epub 2016 Jan 14.
- Truong SL, Nivene I, Saad F, Robinson PC, Cowderoy G, Lim I, et al. Consensus statements on the imaging of axial spondyloarthritis in Australia and New Zealand. J Med Imaging Radiat Oncol. 2017;61(1):58-69.
- Bray TJP, Jones A, Bennett AN, Conaghan PG, Grainger A, Hodgson R, et al. British Society of Spondyloarthritis (BRITSpA). Recommendations for acquisition and interpretation of MRI of the spine and sacroiliac joints in the diagnosis of axial spondyloarthritis in the UK. Rheumatology (Oxford). 2019;58(10):1831-8. Doi: 10.1093/rheumatology/kez173
- De Hooge M, van den Berg R, Navarro-Compán V, Reijnierse M, van Gaalen F, Fagerli K, et al. Patients with chronic back pain of short duration from the SPACE cohort: which MRI structural lesions in the sacroiliac joints and inflammatory and structural lesions in the spine are most specific for axial spondyloarthritis? Ann Rheum Dis. 2016;75(7):1308-14. doi: 10.1136/annrheumdis-2015-207823. Epub 2015 Aug 18.
- Krohn M, Braum LS, Sieper J, Song IH, Weiss A, Callhoff J, et al. Erosions and fatty lesions of sacroiliac joints in patients with axial spondyloarthritis: evaluation of different MRI techniques and two scoring methods. J Rheumatol. 2014;41(3):473-80. doi: 10.3899/jrheum.130581. Epub 2014 Feb 1.
- Rueda JC, Arias-Correal S, Vasquez AY, Calvo E, Peña P, Porras M, et al. Interobserver Agreement in Magnetic Resonance of the Sacroiliac Joints in Patients with Spondyloarthritis. Int J Rheumatol. 2017;2017:3143069. doi: 10.1155/2017/3143069. Epub 2017 Feb 13.
- Zarco P, Almodóvar R, Bueno Á, Molinero LM; SCAISS Study Group. Development and validation of SCAISS, a tool for semi-automated quantification of sacroilitis by magnetic resonance in spondyloarthritis. Rheumatol Int. 2018;38(10):1919-1926. doi: 10.1007/s00296-018-4104-3. Epub 2018 Jul 18
- Ez-Zaitouni Z, Bakker PA, van Lunteren M, de Hooge M, van den Berg R, Reijnierse M, et al. The yield of a positive MRI of the spine as imaging criterion in the ASAS classification criteria for axial spondyloarthritis: results from the SPACE and DESIR cohorts. Ann Rheum Dis. 2017;76(10):1731-1736. doi: 10.1136/annrheumdis-2017-211486. Epub 2017 Jun 29.
- Lorenzin M, Ortolan A, Frallonardo P, Vio S, Lacognata C, Oliviero F, et al. Spine and sacroiliac joints on magnetic resonance imaging in patients with early axial spondyloarthritis: prevalence of lesions and association with clinical and disease activity indices from the Italian group of the SPACE study. Reumatismo. 2016;68(2):72-82. doi: 10.4081/reumatismo.2016.885.
- Devauchelle-Pensec V, D'Agostino MA, Marion J, Lapierre M, Jousse-Joulin S, Colin D, et al.; Study Group of Spondylarthritis. Computed tomography scanning facilitates the diagnosis of sacroiliitis in patients with suspected spondylarthritis: results of a prospective multicenter French cohort study. Arthritis Rheum. 2012;64(5):1412-9. doi: 10.1002/art.33466.
- Chan J, Sari I, Salonen D, Inman RD, Haroon N. Development of a screening tool for the identification of sacroiliitis in computed tomography scans of the abdomen. J Rheumatol. 2016 Sep;43(9):1687-94. doi: 10.3899/jrheum.150939. Epub 2016 Jul 15
- Li SG, Liu X, Zhou H, Zhang Q. Interrater reliability and radiation dosage of oblique coronal computed tomography for sacroiliitis in comparison with axial computed tomography. Br J Radiol. 2018;91(1081):20150700. doi: 10.1259/bjr.20150700. Epub 2017 Nov 3.
- Mohammadi A, Ghasemi-rad M, Aghdashi M, Mladkova N, Baradaransafa P. Evaluation of disease activity in ankylosing spondylitis; diagnostic value of color Doppler ultrasonography. Skeletal Radiol. 2013;42( 2):219-24. doi: 10.1007/s00256-012-1412-7. Epub 2012 May 3.
- Zhu J, Xing C, Jiang Y, Hu Y, Hu B, Wang N.Evaluation of complex appearance in vascularity of sacroiliac joint in ankylosing spondylitis by color Doppler ultrasonography. Rheumatol Int. 2012;32(1):69-72. doi: 10.1007/s00296-010-1543-x. Epub 2010 Jul 25.
- Bandinelli F, Melchiorre D, Scazzariello F, Candelieri A, Conforti D, Matucci-Cerinic M. Clinical and radiological evaluation of sacroiliac joints compared with ultrasound examination in early spondyloarthritis. Rheumatology (Oxford). 2013;52(7):1293-7. doi: 10.1093/rheumatology/ket105. Epub 2013 Mar 26.
- Hamdi W, Bouaziz Chelli M, Ghannouchi MM, Hawel M, Ladeb MF, Kchir MM. Performance of ultrasounds compared with radiographs to detect chronic enthesitis signs in patients with ankylosing spondylitis. Rheumatol Int. 2013;33(2):497-9. doi: 10.1007/s00296-011-2174-6.
- Polachek A, Cook R, Chandran V, Gladman DD, Eder L.The association between sonographic enthesitis and radiographic damage in psoriatic arthritis. Arthritis Res Ther. 2017;19(1):189. doi: 10.1186/s13075-017-1399-5.
- Ebstein E, Coustet B, Masson-Behar V, Forien M, Palazzo E, Dieudé P1, et al. Enthesopathy in rheumatoid arthritis and spondyloarthritis: an ultrasound study. Joint Bone Spine. 2018 Oct;85(5):577-581. doi: 10.1016/j.jbspin.2017.11.014.
- 54 Kim YI, Suh M, Kim YK, Lee HY, Shin K. The usefulness of bone SPECT/CT imaging with volume of interest analysis in early axial spondyloarthritis.BMC Musculoskelet Disord. 2015;16:9. doi: 10.1186/s12891-015-0465-x.
- Ouichka R, Bouderraoui F, Raynal M, Melchior J, Morel O, Blum A, et al. Performance of 18F-sodium fluoride positron emission tomography with computed tomography to assess inflammatory and structural sacroiliitis on magnetic resonance imaging in axial spondyloarthritis. Clin Exp Rheumatol. 2019; 37(1):19-25. Epub 2018 Dec 19.
- Braun J, Baraliakos X, Hermann KG, Xu S, Hsu B. Serum C-reactive Protein Levels Demonstrate Predictive Value for Radiographic and Magnetic Resonance Imaging Outcomes in Patients with Active Ankylosing Spondylitis Treated with Golimumab. J Rheumatol. 2016;43(9):1704-12.
- Inman RD, Baraliakos X, Hermann KA, Braun J, Deodhar A, van der Heijde D et al. Serum biomarkers and changes in clinical/MRI evidence of golimumab-treated patients with ankylosing spondylitis: results of the randomized, placebo-controlled GO-RAISE study. Arthritis Res Ther. 2016;18(1):304.
- Kchir MM, Hamdi W, Laadhar L, Kochbati S, Kaffel D, Saadellaoui K, et al. HLA-B, DR and DQ antigens polymorphism in Tunisian patients with ankylosing spondylitis (a case–control study). Rheumatol Int. 2010;30:933–9
- D'Angelo S, Mennillo GA, Cutro MS, Leccese P, Nigro A, Padula A, et al. Sensitivity of the Classification of Psoriatic Arthritis Criteria in Early Psoriatic Arthritis.J Rheumatol 2009;36: 368–70.
- Baillet A, Gossec L, Carmona L, Wit Md, van Eijk-Hustings Y, Bertheussen H , et al. Points to consider for reporting, screening and preventing selected comorbidities in chronic inflammatory rheumatic diseases in daily practice: A EULAR initiative. Ann Rheum Dis 2016;75:965–73
- Moltó A, Paternotte S, Comet D, Thibout E, Rudwaleit M, Claudepierre P et al. Performances of the Assessment of SpondyloArthritis International Society axial spondyloarthritis criteria for diagnostic and classification purposes in patients visiting a rheumatologist because of chronic back pain: results from a multicenter, cross-sectional study. Arthritis Care Res (Hoboken). 2013;65(9):1472-81.
- Maharaj AB, Govender J, Maharaj K, Rajkaran M, Tak PP. Summary of Sensitivity and Specificity for Psoriatic Arthritis in a South African Cohort according to Classification Criteria. J Rheumatol. 2015;42(6):960-2.
- van der Heijde D, Deodhar A, Inman RD, Braun J, Hsu B, Mack M. Comparison of three methods for calculating the Bath Ankylosing Spondylitis Metrology Index in a randomized placebo-controlled study. Arthritis Care Res (Hoboken). 2012 ;64(12):1919-22.
- Bautista-Molano W, Navarro-Compán V, Landewé RB, Boers M, Kirkham JJ, van der Heijde D. How well are the ASAS/OMERACT Core Outcome Sets for Ankylosing Spondylitis implemented in randomized clinical trials? A systematic literature review. Clin Rheumatol. 2014;33(9):1313-22.
- Kaeley GS, Eder L, Aydin SZ, Gutierrez M, Bakewell C. Enthesitis: A hallmark of psoriatic arthritis. Semin Arthritis Rheum. 2018; 48(1):35-43.
- Mandl P, Navarro-Compán V, Terslev L, Aegerter P, van der Heijde D, D'Agostino MA et al. EULAR recommendations for the use of imaging in the diagnosis and management of spondyloarthritis in clinical practice. Ann Rheum Dis. 2015;74(7):1327-39.
- Ibrahim A, Gladman DD, Thavaneswaran A, Eder L, Helliwell P, Cook RJ et al. Sensitivity and Specificity of Radiographic Scoring Instruments for Detecting Change in Axial Psoriatic Arthritis. Arthritis Care Res (Hoboken). 2017;69(11):1700-1705.
- Ramiro S, Claudepierre P, Sepriano A, van Lunteren M, Molto A, Feydy A et al. Which scoring method depicts spinal radiographic damage in early axial spondyloarthritis best? Five-year results from the DESIR cohort. Rheumatology (Oxford). 2018;57(11):1991-2000.
- Pedersen SJ, Poddubnyy D, Sørensen IJ, Loft AG, Hindrup JS, Thamsborg G et al. Course of Magnetic Resonance Imaging-Detected Inflammation and Structural Lesions in the Sacroiliac Joints of Patients in the Randomized, Double-Blind, Placebo-Controlled Danish Multicenter Study of Adalimumab in Spondyloarthritis, as Assessed by the Berlin and Spondyloarthritis Research Consortium of Canada Methods. Arthritis Rheumatol. 2016;68(2):418-29.
- Zabotti A, Bandinelli F, Batticciotto A, Scirè CA, Iagnocco A, Sakellariou G; Musculoskeletal Ultrasound Study Group of the Italian Society of Rheumatology. Musculoskeletal ultrasonography for psoriatic arthritis and psoriasis patients: a systematic literature review. Rheumatology (Oxford). 2017;56(9):1518-32.
- Deminger A, Klingberg E, Geijer M, Göthlin J, Hedberg M, Rehnberg E et al. A five-year prospective study of spinalradiographic progression and its predictors in men and women with ankylosing spondylitis. Arthritis Res Ther. 2018;20 (1):162.
- van Tubergen A, Ramiro S, van der Heijde D, Dougados M, Mielants H, Landewé R. Development of new syndesmophytes and bridges in ankylosing spondylitis and their predictors: a longitudinal study. Ann Rheum Dis. 2012;71(4):518-23.
- Wendling D, Lukas C, Prati C, laudepierre P, Gossec L, Goupille P, et al. 2018 update of French Society for Rheumatology (SFR) recommendations about the everyday management of patients with spondyloarthritis. Joint Bone Spine. 2018;85:275–84.
- Zochling J, van der Heijde D, Burgos-Vargas R, Collantes E, Davis JC Jr, Dijkmans B, et al. ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 2006;65:442–52.
- Braun J, van den Berg R, Baraliakos X. Update of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 2011:896–904.
- Ramiro S, Nikiphorou E, Sepriano A, Ortolan A, Webers C, Baraliakos X et al. ASAS-EULAR recommendations for the management of axial spondyloarthritis: 2022 updateAnn Rheum Dis 2022;0:1–16. doi:10.1136/ard-2022-223296.
- Laatar A, Miladi S, Fazaa A, Tekaya R, Ben Tekaya A, Manaa M et al. Les recommandations de bonne pratique pour la prise en charge thérapeutique des Spondyloarthrites (Traitement biologique exclu). Tunis Med. 2025;103(1):32-43. DOI: 10.62438/tunismed. v103i1.5563
- Tekaya R, Ben Tekaya A, Mahmoud I, Manaa M, Gharsallah I, Testouri N et al. Les recommandations de bonne pratique pour le Traitement des Spondyloarthrites par les Agents Biologiques. Tunis Med. 2025;103(1): 44-52. DOI: 10.62438/tunismed.v103i1.5555